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氫氣水可以治療牙周病

已有 1545 次閱讀 2011-10-15 11:24 |個人分類:飲用氫氣水|系統分類:論文交流|關鍵字:xml office 牙周病 style black

氫氣水可以治療牙周病 www.h2-water.com

Hydrogen-rich water attenuates experimental periodontitis in a rat model.pdf

這是首次將氫氣用在口腔疾病的研究，這一研究的重要性是給我們提供了新的治療疾病類型，但這一疾病的重要性是發病率特別高，大部分人都會在某一階段存在一定的牙齒問題，而牙周病又占比較高的比例。這一疾病不僅適合進行臨床研究，而且適合個人嘗試。氫氣水非常容易獲得，對這個疾病，可以不需要飲用（但不限制），只需要漱口或含在口中就可以達到治療目的。從個人的體會看，口腔疾病，例如口腔潰瘍，直接漱口效果是非常理想的。希望很快將能看到人體試驗的報告。

本研究論文剛剛發表，目前尚沒有獲得全文，只是根據摘要的理解，可能存在偏差，引用請注意查看全文。

http://onlinelibrary.wiley.com/doi/10.1111/j.1600-051X.2011.01801.x/full

活性氧在牙周病的發展過程中發揮重要作用。因為氫氣分子可以作為活性氧清除劑，我們檢測了富氫氣水對大鼠牙周病的治療效果。將縫合線放在大鼠上頜骨臼齒周圍4周誘導牙周病，動物給飲普通水或富氫氣（對牙周病來講，反復用氫氣水漱口，或者用嘴含氫氣更好，不過動物可不會漱口）。結果發現：與正常無牙周病大鼠比較，飲用普通水的牙周病大鼠血清中活性氧隨著時間延長逐漸增加，同時齒槽骨出現中性顆粒細胞浸潤和骨質丟失（大概是牙周病的典型表現）。飲用富氫氣水牙周病大鼠血清中活性氧沒有增加， 4周後齒槽骨8oHdG和硝基酪氨酸表達減少（氧化損傷指標），而且中性顆粒細胞浸潤和骨質丟失也明顯受到保護。而且與炎症有關的信號傳導通路MAPK也受到明顯抑制。

結論：氫氣可以通過降低齒齦周圍炎症氧化損傷預防牙周病。

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Hydrogen-rich water attenuates experimental periodontitis in a rat model

Kenta Kasuyama, Takaaki Tomofuji, Daisuke Ekuni, Naofumi Tamaki, Tetsuji Azuma, Koichiro Irie, Yasumasa Endo， Manabu Morita. Journal of Clinical Periodontology

Keywords:animal studies; antioxidants; hydrogen-rich water; oxidative stress; periodontitis

Abstract

Aim

Reactive oxygen species (ROS) contribute to the development of periodontitis. As molecular hydrogen can act as a scavenger of ROS, we examined the effects of treatment with hydrogen-rich water on a rat model of periodontitis.

Material & Methods

A ligature was placed around the maxillary molars for 4 weeks to induce periodontitis, and the animals were given drinking water with or without hydrogen-rich water.

Results

The rats with periodontitis which were treated with pure water showed a time-dependent increase in serum ROS level. Compared with the rats without periodontitis, the periodontitis-induced rats which were given pure water also showed polymorphonuclear leucocyte infiltration and alveolar bone loss at 4 weeks. Hydrogen-rich water intake inhibited an increase in serum ROS level and lowered expression of 8-hydroxydeoxyguanosine and nitrotyrosine in the periodontal tissue at 4 weeks. Such conditions prevented polymorphonuclear leucocyte infiltration and osteoclast differentiation following periodontitis progression. Furthermore, inflammatory signalling pathways, such as mitogen-activated protein kinases, were less activated in periodontal lesions from hydrogen-rich water-treated rats as compared with pure water-treated rats.

Conclusion

Consuming hydrogen-rich water might be beneficial in suppressing periodontitis progression by decreasing gingival oxidative stress.