台灣氫水實驗室

氫氣水治療化療藥物順鉑引起腎臟毒性的CT研究

已有 2451 次閱讀 2010-6-1 20:37 |個人分類:飲用氫氣水|系統分類:科研筆記|關鍵字:氫氣

本文已經發表在《英國放射學雜誌》去年日本醫科大學太田小組已經發表類似論文。本次文章來自日本大阪大學Kenya Murase小組，不是一個單位，儘管都在東京。本研究採用了一個新的檢測方法，對動物進行了多層螺旋CT動態增強掃描（dynamic contrast-enhanced CT）檢測腎臟功能，結果發現氫氣水確實能保護腎臟功能，與血清學檢測結果一致。沒看全文，大概結果如此。

這個雜誌比較一般，發表這個雜誌的唯一理由是採用了這個研究方法，如果採用MRI，那麼就可以走類似路子了。

明顯不足是研究內容實在太少，屬於填縫性論文。不過採用這個“新”技術，仍值得鼓勵提倡。

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Experimental verification of protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats using dynamic contrast-enhanced CT

A Kitamura, BSc ¹ S Kobayashi, BSc ¹ T Matsushita, BSc ¹ H Fujinawa, PhD ² and K Murase, PhD ¹

¹ Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan ² I'rom Pharmaceutical, Tokyo 141-0032, Japan

Correspondence: Dr Kenya Murase, Department of Medical Physics and Engineering, Division of Medical Technology and Science, Faculty of Health Science, Graduate School of Medicine, Osaka University, 1-7 Yamadaoka, Suita, Osaka 565-0871, Japan.

E-mail: murase@sahs.med.osaka-u.ac.jp

Our aim was to assess the protective effect of hydrogen-rich water against cisplatin-induced nephrotoxicity in rats usingdynamic contrast-enhanced CT (DCE-CT). DCE-CT studies were performed in 30 rats (8 weeks old) on days 0, 2, 4 and 7 using multidetector row CT. The rats were divided into three groups: a control group (n = 6) with free access to standard water and without cisplatin injection, a non-treatment group (n = 12) with free access to standard water and injected with cisplatin (3.6 mg kg^–1 body weight) intraperitoneally on day 0 and a treatment group (n = 12) with free access to hydrogen-rich water starting from 7 days before cisplatin injection. The contrast clearance per unit renal volume (K₁) was estimated from the DCE-CT data using the Patlak model. The contrast clearance of the entire kidney (K) was obtained by multiplying K₁ by the renal volume. The serum creatinine level was also measured on day 7. The K₁ and K values normalised by those on day 0 in the treatment group were significantly greater than those in the non-treatment group on days 2, 4 and 7. There were no significant differences in the normalised K value between the treatment and control groupson days 2 and 7. The serum creatinine level in the treatment group was significantly lower than that in the non-treatmentgroup and was not significantly different from that in the control group. This study demonstrated that hydrogen-rich water ameliorates renal dysfunction due to cisplatin-induced nephrotoxicity in rats.

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