台灣氫水實驗室

這是目前唯一的人類為研究對象的論文。研究的方法比較簡單，嚴格講，不能算糖尿病，只是高血糖患者。飲用含氫水8週，2月後。發現患者的血糖有明顯降低，胰島素有一定升高。很奇怪。 Oxidative stress is recognized widely as being associated with various disorders including 
diabetes, hypertension, and atherosclerosis. It is well established that hydrogen has a reducing action. 
We therefore investigated the effects of hydrogen-rich water intake on lipid and glucose metabolism 
in patients with either type 2 diabetes mellitus (T2DM) or impaired glucose tolerance (IGT). We 
performed a randomized, double-blind, placebo-controlled, crossover study in 30 patients with 
T2DM controlled by diet and exercise therapy and 6 patients with IGT. The patients consumed either 
900 mL/d of hydrogen-rich pure water or 900 mL of placebo pure water for 8 weeks, with a 12-week 
washout period. Several biomarkers of oxidative stress, insulin resistance, and glucose metabolism, 
assessed by an oral glucose tolerance test , were evaluated at baseline and at 8 weeks. Intake of 
hydrogen-rich water was associated with significant decreases in the levels of modified low-density 
lipoprotein (LDL) cholesterol (ie, modifications that increase the net negative charge of LDL), small 
dense LDL, and urinary 8-isoprostanes by 15.5% (P b .01), 5.7% (P b .05), and 6.6% (P b .05), 
respectively. Hydrogen-rich water intake was also associated with a trend of decreased serum 
concentrations of oxidized LDL and free fatty acids, and increased plasma levels of adiponectin and 
extracellular-superoxide dismutase. In 4 of 6 patients with IGT, intake of hydrogen-rich water 
normalized the oral glucose tolerance test. In conclusion, these results suggest that supplementation 
with hydrogen-rich water may have a beneficial role in prevention of T2DM and insulin resistance. 
© 2008 Elsevier Inc. All rights reserved.全文